Open in a separate window LM: Left ventricular ejection fraction; WMA:
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This article has been cited by other articles in PMC. Abstract Acute fulminant myocarditis AFM is a serious heart disease with limited treatment.
This observational retrospective study aimed to investigate whether intravenous immunoglobulin IVIG was able to improve left ventricular function and reduce the episodes of arrhythmia in adult patients with AFM. A cohort of 58 patients was included in the study.
This retrospective study suggested that the use of IVIG for the treatment of AFM may be associated with improved left ventricular function and reduced episodes of fulminant arrhythmias. The initial severe presentation and favorable long-term prognosis of AFM is associated with left ventricular function 3.
AFM involves serious arrhythmias, which occasionally have lethal consequences due to cardiac dysfunction 4.
Intravenous immunoglobulin IVIG has been used to treat inflammatory and autoimmune diseases 56. Immune or autoimmune mechanisms may be involved in the pathogenesis of myocarditis 7.
The administration of immunoglobulin was reported to be of clinical value against certain viral infections due to the neutralization of the virus, the blockade of Fc receptors and the neutralization of a microbial toxin 5689. Although the immunosuppressive therapy has yielded conflicting results in patients with acute myocarditis 10previous studies demonstrated the effect of the IVIG in acute myocarditis 9 The beneficial effect of IVIG on myocarditis was demonstrated in an animal study using polyclonal immunoglobulin In the pediatric population, IVIG was associated with improved recovery of left ventricular function 9.
This retrospective study was performed to evaluate the effect of IVIG on the cardiac function and cardiac rhythm of adult patients with AFM.
The patients were included according to the following criteria: Patients with coronary artery disease, long-standing dilated cardiomyopathy, structural heart disease, systemic autoimmune disease, Kawasaki disease, the presence of active infection and other specific causes of acute cardiomyopathy were excluded.
Data were collected through patient chart review. Data collection Clinical data and demographic information were collected by the review of the medical records of the enrolled patients. Blood samples were obtained to analyze myocardial enzymes, troponin, brain natriuretic peptide, C-reactive protein and erythrocyte sedimentation rate at baseline.
Echocardiography, electrocardiography and h ambulatory electrocardiography were performed prior to and following treatment.
Gender, age, cardiac function classification, parameters of echocardiography, blood test data and incidence of complications were compared between the two groups. Echocardiography Echocardiography data were collected by previously reported methods The data of left ventricle and left atrium were measured on parasternal long-axis view, and the data of right ventricle and right atrium were measured on apical four-chamber view.
The recovery of left ventricular function was assessed in hospital and post-treatment four weeks. The variables in Fig. Data that followed an asymmetric distribution are presented as medians and interquartile ranges, and were compared using the Kruskal-Wallis nonparametric test. All statistical analyses were performed with the Statistical Package for Social Sciences version Most cases of myocarditis have no symptoms and are only identified by an electrocardiogram or by blood tests that detect heart injury.
Because myocarditis is rare, the best way to diagnose and treat the disease is not known, but research is being done.
Dec 19, · A population study in Finland found that, in a study of more than , healthy young male military recruits, 98 cases had myocarditis mimicking myocardial ischemia, 1 case presented as sudden death, and 9 cases presented as recent-onset dilated cardiomyopathy.
Severe myocarditis weakens your heart so that the rest of your body doesn't get enough blood. Clots can form in your heart, leading to a stroke or heart attack.
Treatment for myocarditis depends on the cause. Myocarditis care at Mayo Clinic. Symptoms. If you have a mild case of myocarditis or are in the early stages, you might have no symptoms.
Myocarditis, also called inflammatory cardiomyopathy is a medical condition that involves inflammation of the cardiac muscle of the heart called myocardium, specifically the middle layer of the.
Eosinophilic myocarditis is a subtype of myocarditis in which cardiac tissue is infiltrated by another type of pro-inflammatory blood cell, the eosinophil.
Eosinophilic myocarditis is further distinguished from non-eosinophilic myocarditis by having a different set of causes and recommended treatments. Hufnagel G et al. () The European Study of Epidemiology and Treatment of Cardiac Inflammatory Diseases (ESETCID).
() A case of giant cell myocarditis and malignant thymoma: a postmortem diagnosis by needle biopsy. to maintain blood pressure and improve cardiac output.
If the patient does not respond to aggressive supportive.